updated 8:41 a.m. PT, Tues., March. 11, 2008

Dallas Hextell was already a miracle to parents Cynthia and Derak, after they spent three years trying to get pregnant.

But now he is looking like a medical miracle to the rest of the world.

The 2-year-old son of the Sacramento, Calif., couple was diagnosed with cerebral palsy, but is now showing fewer signs of the disorder and marked improvement after an infusion of his own stem cells — made possible by the preservation of his own cord blood shortly before birth.

Derak Hextell now believes his son will be cured of the incurable malady.

“[Dallas’ doctors] said by the age of 7, there may be no signs of cerebral palsy at all,” Hextell told TODAY co-host Meredith Vieira while holding a curious Dallas on his lap. “So he’s on his way, as far as we’re concerned.”

For Cynthia Hextell, the changes in Dallas just five days after the intravenous infusion of his cord blood cells are not coincidental.

“[He’s changed] almost in every way you can imagine, just from five days afterwards saying ‘mama’ and waving,” she said. “We just feel like right now he really connects with you.

“It just seemed like a fog was over him before, like he just really wasn’t there. There was kind of, like a glaze in his eyes. Now, as you can see, you can’t get anything past him.”

A difficult start
The joy of Dallas’ birth in 2006 was met with gradual heartbreak as he was unable to feed from his mother. He was constantly crying and rarely opened his eyes. At five months, Dallas had trouble balancing himself and his head was often cocked to one side.

The Hextells switched pediatricians when Dallas was eight months old and was diagnosed with cerebral palsy — a group of nonprogressive disorders that affect a person’s ability to move and to maintain balance and posture.

Various studies show that the damage to the motor-control centers of the young, developing brain that causes CP occurs during pregnancy, although there are smaller percentages of the disorder occurring during childbirth and after birth through the age of 3.

“I think it’s important to remind people that cerebral palsy has to do with the motor part of the brain and usually kids don’t deteriorate,” said Dr. Nancy Snyderman, NBC News’ chief medical editor. “But they have significant motor problems, which explains why he wasn’t a good sucker when he was breast-feeding as a baby and all of this colicky stuff that sort of confused the diagnosis.”

There is no known cure for cerebral palsy, and the treatments to help manage its debilitating effects make it the second-most expensive developmental disability to manage over a person’s lifetime, behind mental disabilities.

At 18 months, Dallas had very limited motor skills. He could not crawl, clap or sit up and he communicated only through screaming brought on mostly by pain and frustration.

Life-changing decision
During her pregnancy, Cynthia Hextell had done thorough Web research on health issues relating to childbirth and came across a pop-up ad for Cord Blood Registry, the world’s largest family cord blood stem cell bank. The San Bruno, Calf.-based company has preserved cord blood stem cells for more than 200,000 newborns throughout the world.

Hextell said the cost of saving Dallas’ cord blood — about $2,000 and not covered by insurance — was off-putting. But she ultimately registered for CBR, thinking she would rather put up the money and not use it rather than have saved it and regretted it later.

(Cord Blood Registry spokesman David Zitlow said the procedure costs $2,000 for processing and $120 per year for storage.)

“We had a perfectly healthy pregnancy, but it did take us three years to get pregnant,” Cynthia Hextell told Vieira. “It was a good chance he was going to be our only child, so that was one thing that if we were going to do it, this was our only chance.

“Heart disease ran in [Derak Hextell’s] family. I was adopted, so I knew if we ever needed something, Dallas and I were the only ones [who could provide a genetic match]. So those were things [we considered], but nothing like I thought something was going to be wrong with my child. Literally, it took us until about two weeks before our due date to make the final decision because it is expensive.”

After Dallas was diagnosed, the Hextells traveled to Duke University, where doctors were using cord blood as part of a clinical trial to treat a small number of children who had cerebral palsy or brain damage. Mrs. Hextell called some of the parents of the children and all of them reported tangible improvement in their children following the transplant of stem cells, evidenced in better speech and motor skills.

So the Hextells agreed to infuse Dallas’ own stem cells back into his bloodstream last July, a procedure that took less than an hour.

Within five days, a different child emerged — laughing, clapping, waving and reacting.

“We think [the transfusion] has a real big part to do with it because it was such a drastic change within five days of the procedure taking place,” Derak Hextell said. “It had to be because he wasn’t reaching the milestones that he’s reaching now. He was falling further and further behind.”

“Before he went to Duke, we were trying to teach him to use a walker,” Cynthia Hextell said. “Now he walks with no assistance at all.”

Saving the cells
Although Dallas’ case was not part of a controlled case study, Snyderman said it should not be overlooked in the progressing studies of stem cell treatments.

“I think the thing that medicine has not done very well is we haven’t made a big enough deal about anecdotes,” she said. “This is not a controlled case study. It’s not a randomized clinical trial. But it is a child with a diagnosis who got a transfusion of stem cells and not only stopped the deterioration of his problems, [but] he’s doing better.

“So I take it very seriously. And I think it’s an extraordinary reminder that cord blood, that stuff that is thrown away with the placenta in the emergency room as sort of medical waste, can have extraordinary applications. We’re all offered it in the delivery room.”

Snyderman didn’t have to convince one person about the promise of those stem cells.

Said Cynthia Hextell: “They’re like gold.

The latest indicator that there is more to breast milk than providing food for a baby’s physical needs came recently when Dr. Mark Cregan, a molecular biologist with The University of Western Australia, discovered stem cells in breast milk. Not only is this a very exciting revelation, but Dr. Cregan is very hopeful that this is the first of many discoveries in the potency of breast milk.

“We already know how breast milk provides for the baby’s nutritional needs, but we are only just beginning to understand that it probably performs many other functions,” Dr. Cregan recently said. He believes that breast milk takes over from the placenta at birth providing for all of a baby’s genetic developmental needs. “It is setting the baby up for the perfect development,” stated Dr. Cregan.
It has already been established that breastfed babies have an IQ edge over their formula-fed peers. There are also a host of immune-system boosts that a baby receives when breastfed. Scientists are now maintaining that these health benefits carry a baby on into their adult life as well.

Dr. Cregan’s message is clear. “The point is that many mothers see milk as identical – formula milk and breast milk look the same so they must be the same. But we know now that they are quite different and a lot of the effects of breast milk versus formula don’t become apparent for decades. Formula companies have focused on matching breast milk’s nutritional qualities but formula can never provide the developmental guidance,” he says.

Dr. Cregan received his PhD at the University of Western Australia, specializing in the cellular composition of breast milk. The focus of Dr. Cregan’s research at this time is the cellular composition of breast milk in relation to milk synthesis, milk removal and potential lactation difficulties, as well as the potential use of breast milk in breast cancer research.

His research team cultured the cells of human breast milk and the result was positive for the stem cell marker, nestin. Further analysis has shown that the cells could potentially be “reprogrammed” to pattern themselves to many types of human tissue.

Additionally, the immunity cells found in breast milk have been found to survive a baby’s digestive process and could possibly be used to provide a method of developing targets to conquer certain bacteria and viruses.

Dr. Cregan recently presented his findings to 200 of the world’s leading experts in the field. He stated, “We have shown these cells have all the physical characteristics of stem cells. What we will do next is to see if they behave like stem cells.” If this is found to be the case, the stem cells in breast milk will provide science with an ethical method of harvesting stem cells for research.

Source: www.naturalnews.com